In case of the application of Hazen-Williams C for design, operation or maintenance of water supply system, field situations always should be reflected on the factors. In this study, the relationships between C factors and influencing factors are analyzed using statistical techniques with 174 measured C factor data collected in periodic inspection for safety diagnosis in multi-regional water supply systems. To analyze their relationships, cross analysis, one-way ANOVA, correlation analysis were conducted. Analysis results showed that C factors had high correlations with both of elapsed year and pipe diameter and were relatively highly affected by coating material among influencing factors with the categorical type. On the other hand, elapsed year, pipe diameter and water type were meaningful influencing factors according to the results of multiple regression analysis. The Cluster analysis revealed that C factors had a tendency of being fundamentally classified on the basis of the elapsed year of about 20 years and the pipe diameter of 1500mm. Although C factors were generally greatly affected by elapsed year, size of pipe diameter relatively had an large influence on values of them in case of large diameter pipes. Lastly, It can be suggested that C factor estimation formulas using multiple regression analysis and clustering analysis in this study, can be applied as decision standards of C factor in multi-regional water supply systems.